The role of luteinizing hormone in the pathogenesis of hyperadrenocorticism in neutered ferrets | Semantic Scholar (2024)

To determine plasma concentrations of adrenocorticotrophic hormone (ACTH) and α-melanocyte stimulating-hormone (α-MSH) in healthyferrets and ferrets with hyperadrenocorticism, plasma concentrations were measured by radioimmunoassay.

An LH-dependent form of Cushing’s syndrome occurs in spayed female dogs, and that it is more likely to occur when female dogs are spayed later in life.

Clinical signs and sex steroid measurements are important in diagnosing hyperadrenocorticism in ferrets and a ranking system for the severity of alopecia was developed.

Results showed that GonaCon provided relief from ACD by causing production of antibodies to GnRH, probably suppressing production and/or release of LH, and caused many ACD symptoms to disappear, allowing the ferrets to return to a normal life.

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Median plasma concentrations of 17-hydroxyprogesterone, androstenedione, and dehydroepiandrosterone sulfate were significantly higher in ferrets with adrenal gland disease, compared with concentrations in clinically normal ferrets.

Results suggest that leuprolide can be safely used to temporarily eliminate clinical signs and reduce sex hormone concentrations in ferrets with adrenocortical diseases.

It is concluded that pituitary-dependent hyperadrenocorticism in the dog is a valid model for study of the pathogenesis of the disease in man.

Five ferrets died in the immediate postoperative period, and follow-up information was available for the remaining 34, 1 to 34 months after surgery.(ABSTRACT TRUNCATED at 250 words)

The observations indicate that vascular pericytes may play a role in follicular development; LHR expression in granulosa may require an interaction of macrophages, oocytes, and cumulus cells; and thecal hypertrophy accompanied by enhanced L HR expression occurs on follicles undergoing atresia.

The aberrant endocrine behaviour of this gonadotrophin‐responsive testosterone‐secreting adenoma of adrenal zona reticularis cell origin can be explained by ectopic functional hCG receptors and the lack of 21‐hydroxylase activity.

It is concluded that determination of UCCR values was useful in the diagnosis of hyperadrenocorticism associated with adrenal neoplasia in domestic ferrets.

Age at neutering may be associated with age at development of hyperadrenocorticism in ferrets, and a significant linear correlation between age at neutered and age at time of diagnosis was detected.

A woman with bilateral adrenal hyperplasia and corticotropin-independent Cushing's syndrome that was clinically manifested transiently during her pregnancies and became constant only after menopause is described, where the patient's cortisol secretion was stimulated by luteinizing hormone.

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